Clinical Trial Sponsors: National Taiwan University Hospital

  Source:		NCT00172263

    		The Interaction Between Severe
     		Acute Respiratory Distress Syndrome Viral
			Proteins and Monocytes


			First Update September 12, 2005
			Last Update December 6, 2012

			Brief Summary
			Severe acute respiratory syndrome (SARS) is a
			new threat to public health since November,
			2002. The SARS is highly contagious and is
			believed to be transmitted by person-to-person
			through droplet and direct contact. The
			patients present with fever, chills, cough,
			myalgia, dyspnea, and diarrhea. The symptoms
			aggravate in the second week and nearly 40%
			of the patients develop respiratory failure that
			requires assisted ventilation. The mortality rate
			is reported as 6.5%-7%. After several months,
			the world scientists found the etiology to be a
			new coronavirus not belonging to the previous
			coronavirus group I, II and III. The new virus is
			called SARS associated coronavirus
			(SARS-CoV). Although the high morbidity and
			mortality of SARS occurred in adults, there was
			rare mortality reported in the children. The
			report from Hong Kong pointed out that the
			symptoms of SARS in younger children were
			milder and the clinical course was not as
			aggressive as in adults. Therefore, the aim of
			the project is to design the experiment to see
			the differences of immunological responses to
			SARS-CoV protein in healthy younger children,
			teenagers, and adults. The investigators hope
			that the result could explain the reason for
			milder disease in younger children and the
			immunological pathogenesis of SARS.

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