Clinical Trial Sponsors: National Taiwan University Hospital

  Source:		NCT00173459

    		Dynamic Profiles of Cytokine/Chemokine in
     		Severe Acute Respiratory Syndrome


			First Update September 12, 2005
			Last Update September 12, 2005

			Brief Summary
			Severe acute respiratory syndrome (SARS) is
			an emerging infectious disease caused by a
			novel coronavirus (SARS-CoV). The major
			clinical features of SARS include fever,
			dyspnea, lymphopenia, and a rapid progression
			of pulmonary infiltrates on chest radiologic
			images. The SARS-related deaths have
			resulted mainly from pulmonary complications,
			including progressive respiratory failure due to
			alveolar damage and
			acute respiratory distress syndrome (ARDS).
			Pathological changes in SARS suggest that
			SARS sequelae such as infiltration of PMN in
			lung tissue, multiple organ dysfunction and
			ARDS have been associated with cytokines and
			chemokine dysregulation. Some patients still
			manifested lung injury at a time when the
			viral load was falling also supports the immune
			nature of the lung damage. We therefore
			undertook an analysis of dynamic production of
			cytokine/chemokines in SARS patients with an
			initial normal chest radiograph in order to
			improve understanding of disease pathogenesis
			and improve patient management.

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